Gene de la preprotachykinine-c codant le precurseur d'une tachykinine denommee substance z

Preprotachykinin-c gene encoding substance z tachykinin precursor

Abstract

The present invention provides a new mammalian preprotachykinin-c gene (PPT-C) which encodes a precursor protein for a new tachykinin peptide called Substance Z. Substance Z has vasodilative effects and is expressed in hematopoietic tissues. The identification and isolation of this peptide provides the basis for development of therapeutic strategies for immune disorders in which Substance Z is involved as well as for development of antibodies and antagonists for the peptide.

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